Janean E. Holden
Janean E. Holden, PhD, RN, FAAN
University of Michigan School of Nursing
400 North Ingalls Building
Ann Arbor, MI 48109-5482
Scholarly Expertise / Activity
Interests:
- Hypothalamic pain modulation
- Neuropathic and nociceptive pain
- Sex differences in pain
Dr. Holden received her doctorate in nursing at the University of Michigan and completed a three year post-doctoral experience in pharmacology at the University of Illinois at Chicago as part of an NINR funded training grant in biobehavioral nursing. She is an expert in preclinical pain mechanisms research and her work focuses specifically on the mechanisms by which hypothalamic nuclei inhibit the processing of nociceptive input at the spinal cord level. Her past work has linked the lateral and posterior hypothalamus to brainstem noradrenergic and serotonergic neurons known to project to the dorsal horn and inhibit acute pain while her current work has expanded her model to include neuropathic pain and to examine sex differences in pain processing, modulation, and perception.
Current Research Grants and Programs:
- Forebrain Modulation of Pain; NIH, NINR
- Hypothalamic Modulation of Chemotherapy-induced Neuropathic Pain; Neuroscience Nursing, Integra Foundation
Teaching
Dr. Holden’s area of teaching expertise lies in pathophysiology and pharmacology. Prior to becoming a faculty member at the U-M School of Nursing, she taught at both the undergraduate and graduate levels. More recently she has taught graduate pathophysiology for master’s advanced practice students but she is looking forward to co-teaching undergraduate pathophysiology and physiology in the forthcoming academic year.
Dr. Holden's teaching philosophy is grounded in the idea that college students are adult learners and, as such, are largely responsible for their own learning with her role being to facilitate understanding of core concepts through exploration. For her, the most exciting students are those who engage with the intricacies of physiology and how the body responds to illness.
Affiliations / Service
- Member, NSAA Study Section, NIH, 2009-present
- Member, International Association for the Study of Pain, 1996-present
- Member, Council for the Advancement of Nursing Science
- Member, Midwest Nursing research Society, 1988-present (Vice President, 2006-2010)
- Member, MNRS Foundation; 2006-present (secretary-Treasurer)
Notable Awards / Honors
- Fellow, American Academy of Nursing, 2009-present
- Ehrlich II World Wide Conference On Magic Bullets; invited to compete for Ehrlich Prize, 2008
- Presidential Early Career Award for Scientists and Engineers, presented at the White House, 2000
- Senior Scientist Recognition Award, Midwest Nursing Research Society, 2009
- Outstanding Alumni Award, University of Michigan School of Nursing, 2001
- Inducted into the UIC College of Nursing Academy of Distinguished Teachers, 2000
Education
- PhD, University of Michigan, Ann Arbor, MI, 1993
- MS, University of Michigan, Ann Arbor, MI, 1987
- BSN, University of Utah, Salt Lake City, UT, 1974
Publication Highlights
- Prasertsri N, Holden JE, Keefe FJ, & Wilkie DJ (in press). Repressive coping style: Relationships with pain, pain coping strategies, and depression in lung outpatient cancer patients. Lung Cancer
- Holden JE (2009). Basic science is not nursing research? If it isn’t, what is? Western Journal of Nursing Research, 31(7):815-817.
- Holden JE, Pizzi JA, Jeong Y (2009). An NK1 receptor antagonist microinjected into the periaqueductal gray blocks lateral hypothalamic-induced antinociception in rats. Neuroscience Letters, 453:115-119. (PMID: 19356605)
- Jeong Y, & Holden JE (2009). Lateral hypothalamus-induced alpha-adrenoceptor mediated nociceptive modulation acts on C-fibers in rat. Biological Research for Nursing, 10(4):331-339. (PMID: 19114413)
- Jeong Y, & Holden JE (2009). The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain. Neuroscience, 159:1414-1421. (PMID: 19409203)
- Jeong Y, & Holden JE (2008). Commonly used preclinical models of pain. Western Journal of Nursing Research, 30:350-364. (PMID: 18029542)
- Holden JE, & Pizzi JA (2008). Lateral hypothalamic-induced antinociception is mediated by a substance P connection with the rostral ventromedial medulla. Brain Research, 1214:40-49. (PMID: 18457815)
- Holden JE, Naleway E, & Jeong Y (2005). Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. Neuroscience, 135:1255-1268. (PMID: 16165284)
- Holden JE, Jeong Y, & Forrest J. (2005). The endogenous opioid system and clinical pain management. AACN Clinical Issues, 16:291-301. (PMID: 16082232)
- Holden JE, & Pizzi JA (2003). The challenge of chronic pain. Advanced Drug Delivery Reviews, 55:935-948. (PMID: 12935938)
- Holden JE, Van Poppel AY, & Thomas S (2002). Antinociception from lateral hypothalamic stimulation is mediated by NK1 receptors in the A7 catecholamine cell group in the rat. Brain Research, 953:195-204. (PMID: 12384253)
- Holden JE & Naleway E (2001). Microinjection of Carbachol in the lateral hypothalamus produces opposing effects on nociception mediated by a1- and a2 - adrenoceptors. Brain Research, 911:27-36. (PMID: 11489441)
- Holden JE, & Proudfit HK (1999) Microinjection of morphine in the A7 catecholamine cell group produces opposing effects on nociception that are mediated by alpha1 and alpha2 adrenoceptors. Neuroscience, 91:979-990. (PMID: 10391476)
- Holden JE, & Proudfit HK (1998). Enkephalin neurons that project to the A7 catecholamine group are located in nuclei that modulate nociception: Ventromedial medulla. Neuroscience, 83:929-947. (PMID: 9483575)
